Title : Mitogen-activated protein kinase pathway was significantly activated in human bronchial epithelial cells by nicotine.

Pub. Date : 2006 May

PMID : 16716121






4 Functional Relationships(s)
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1 Membrane array analysis subsequently suggested that both extracellular signal-regulated kinase (ERK) 1/2 and c-Jun-NH(2)-terminal kinase (JNK) signalings but not p38 MAPK signaling were activated in response to nicotine. Nicotine mitogen-activated protein kinase 3 Homo sapiens
2 Pretreatment of HBECs with specific inhibitors against ERK 1/2 and JNK but not p38 could significantly inhibit nicotine-induced interleukin- 8 production. Nicotine mitogen-activated protein kinase 3 Homo sapiens
3 These results suggest that MAPK pathway may mediate the effect of nicotine through ERK 1/2 and JNK but not p38 in HBECs treated with nicotine. Nicotine mitogen-activated protein kinase 3 Homo sapiens
4 These results suggest that MAPK pathway may mediate the effect of nicotine through ERK 1/2 and JNK but not p38 in HBECs treated with nicotine. Nicotine mitogen-activated protein kinase 3 Homo sapiens