Pub. Date : 2006 Jun
PMID : 16706977
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Both disulfide bond-stabilized variants had improved affinity for von Willebrand factor (VWF). | Disulfides | von Willebrand factor | Homo sapiens |
| 2 | RESULTS: Both disulfide bond-stabilized variants had improved affinity for von Willebrand factor (VWF). | Disulfides | von Willebrand factor | Homo sapiens |
| 3 | In summary, introduction of engineered interdomain disulfides results in FVIIIa variants that resist spontaneous loss of activity while retaining susceptibility to APC proteolytic inactivation and maintaining VWF binding. | Disulfides | von Willebrand factor | Homo sapiens |