Title : Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.

Pub. Date : 2006 Jul 1

PMID : 16697367






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We find that the SPP inhibitor (Z-LL)2-ketone (IC50 = 1.33 microM) and the gamma-secretase potent inhibitors NVP-AHW700-NX (IC50 = 51 nM) and LY411575 (IC50 = 61 nM) but not DAPT dose dependently inhibited SPP but not signal peptidase cleavage. dapt histocompatibility minor 13 Homo sapiens