| Protein Name | histocompatibility minor 13 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 81502 |
| Gene Symbol | HM13 |
| UniProt | Q8TCT9 (HM13_HUMAN), A0A0C4DGU3 (A0A0C4DGU3_HUMAN), A0A0S2Z5V7 (A0A0S2Z5V7_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
435
Total Number of Articles : 597 |
Description |
histocompatibility minor 13 |
| Gene Summary |
The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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