Title : Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation.

Pub. Date : 2006 Jul 14

PMID : 16687396






1 Functional Relationships(s)
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1 Treatment of cells with nocodazole revealed that pseudophosphorylation of T4 at both Thr231/Ser235 and Ser396/Ser404 diminished the ability of tau to protect against microtubule depolymerization, whereas with T4C3 only pseudophosphorylation at Ser396/Ser404 attenuated the ability of tau to stabilize the microtubules. Nocodazole microtubule associated protein tau Homo sapiens