Title : Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.

Pub. Date : 2006 Aug

PMID : 16679385






2 Functional Relationships(s)
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1 Fluoxetine also inhibited CYP2C19-dependent S-mephenytoin 4"-hydroxylation in a time- and concentration-dependent manner in hepatocytes, HLMs, and recombinant CYP2C19 (KI 0.4 microM and kinact 0.5 min(-1)). Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens
2 Fluoxetine also inhibited CYP2C19-dependent S-mephenytoin 4"-hydroxylation in a time- and concentration-dependent manner in hepatocytes, HLMs, and recombinant CYP2C19 (KI 0.4 microM and kinact 0.5 min(-1)). Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens