Pub. Date : 2006 May 15
PMID : 16670331
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | With mouse MD-2 mutants, we show in this study that Gly(59) was found to be a novel critical amino acid for LPS binding outside the region 119-132. | Glycine | toll-like receptor 4 | Mus musculus |
| 2 | MD-2 mutants substituting alanine for Phe(126) or Gly(129) impaired LPS-induced TLR4 clustering, but not LPS binding to TLR4/MD-2, demonstrating that ligand-induced receptor clustering is differentially regulated by MD-2 from ligand binding. | Glycine | toll-like receptor 4 | Mus musculus |
| 3 | MD-2 mutants substituting alanine for Phe(126) or Gly(129) impaired LPS-induced TLR4 clustering, but not LPS binding to TLR4/MD-2, demonstrating that ligand-induced receptor clustering is differentially regulated by MD-2 from ligand binding. | Glycine | toll-like receptor 4 | Mus musculus |