Title : Development of N-2,4-pyrimidine-N-phenyl-N'-alkyl ureas as orally active inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 2.

Pub. Date : 2006 Jul 1

PMID : 16632350






1 Functional Relationships(s)
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1 X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction. Hydrogen mitogen activated protein kinase 14 Rattus norvegicus