Title : F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation.

Pub. Date : 2006 Mar

PMID : 16629121






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have investigated the dephosphorylation of monophosphorylated fludarabine (F-ara-AMP) by the purified cytoplasmic 5"-nucleotidase cN-II using HPLC and NMR. fludarabine 5'-nucleotidase, cytosolic II Homo sapiens
2 These studies clearly showed that cN-II was able to convert F-ara-AMP into its non phosphorylated form, F-ara-A, with a Km in the millimolar range and Vmax = 35 nmol/min/mg, with both methods. fludarabine 5'-nucleotidase, cytosolic II Homo sapiens