Title : XIAP is related to the chemoresistance and inhibited its expression by RNA interference sensitize pancreatic carcinoma cells to chemotherapeutics.

Pub. Date : 2006 Apr

PMID : 16628085






4 Functional Relationships(s)
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1 METHODS: Pancreatic carcinoma cell line SW1990 was exposed to 5-fluorouracil (5-fu) with the concentrations of 1.0 and 10 mug/mL to increase the expression of XIAP. Fluorouracil X-linked inhibitor of apoptosis Homo sapiens
2 METHODS: Pancreatic carcinoma cell line SW1990 was exposed to 5-fluorouracil (5-fu) with the concentrations of 1.0 and 10 mug/mL to increase the expression of XIAP. Fluorouracil X-linked inhibitor of apoptosis Homo sapiens
3 RESULTS: XIAP of SW1990 can be up-regulated with the chemoresistance increasing 1.5- and 4-fold after 10 and 30 days induced by 5-fu. Fluorouracil X-linked inhibitor of apoptosis Homo sapiens
4 The cells apoptosis index induced by 5-fu and gemcitabine increased greatly after XIAP is inhibited by the RNAi plasmid vectors. Fluorouracil X-linked inhibitor of apoptosis Homo sapiens