Title : The role of polyol pathway in high glucose-induced endothelial cell damages.

Pub. Date : 2006 Sep

PMID : 16624439






2 Functional Relationships(s)
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1 Addition of the aldose reductase inhibitor SNK-860 dose-dependently decreased the intracellular sorbitol concentration in HUVECs incubated in high glucose medium, and also significantly suppressed the increases in fragmented DNA, caspase-3 activity and 8-OHdG by conditioning with high glucose medium. Glucose aldo-keto reductase family 1 member B Homo sapiens
2 Addition of the aldose reductase inhibitor SNK-860 dose-dependently decreased the intracellular sorbitol concentration in HUVECs incubated in high glucose medium, and also significantly suppressed the increases in fragmented DNA, caspase-3 activity and 8-OHdG by conditioning with high glucose medium. Glucose aldo-keto reductase family 1 member B Homo sapiens