Title : RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide.

Pub. Date : 2007 Jan

PMID : 16614850






2 Functional Relationships(s)
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1 The addition of ATRA also exhibited additional inhibitory effects on ALDH activity and increased 4-HC toxicity when added to single siRNA aimed at one of the enzymes. Tretinoin aldehyde dehydrogenase 1 family member A1 Homo sapiens
2 On the other hand, ATRA had minimal and insignificant additional inhibitory effects on ALDH enzyme activity when added to a combination of siRNAs against both enzymes, but still increased 4-HC toxicity beyond that seen with RNAi-mediated inhibition of both enzymes together. Tretinoin aldehyde dehydrogenase 1 family member A1 Homo sapiens