Pub. Date : 2006 Jul
PMID : 16611855
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 2 | Concordant with PPARgamma involvement, the PPARgamma-specific antagonist 2-chloro-5-nitro-N-(4-pyridyl)-benzamide (T0070907) blocked 2-AG- and 2-AG ether-mediated IL-2 suppression. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |
| 3 | Together, the aforementioned studies identify PPARgamma as a novel intracellular target of 2-AG, which mediates the suppression of IL-2 by 2-AG in a manner that is independent of CB1 and/or CB2. | glyceryl 2-arachidonate | peroxisome proliferator activated receptor gamma | Mus musculus |