Title : Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation.

Pub. Date : 2006 May

PMID : 16598818






1 Functional Relationships(s)
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1 Collectively these results suggest that EDC such as benzophenone, p-octylphenol, and TBT promote Th2 polarization indirectly via the depletion of glutathione in APC and subsequent modulation of IL-10 and IL-12 production that might result in the exacerbation of allergic diseases. 4-octylphenol interleukin 10 Mus musculus