Title : OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib.

Pub. Date : 2006 Jul 15

PMID : 16597591






1 Functional Relationships(s)
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1 The addition of prazosin, a potent inhibitor of OCT-1 cellular transporter, reduced the IUR and eliminated interpatient variability. Prazosin solute carrier family 22 member 1 Homo sapiens