Pub. Date : 2006 Apr
PMID : 16581535
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Occupational toluene exposure induces cytochrome P450 2E1 mRNA expression in peripheral lymphocytes. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 2 | Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 3 | Toluene induces expression of cytochrome P450 2E1 (CYP2E1), an enzyme involved in its own metabolism and that of other protoxicants, including some procarcinogens. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 4 | Therefore, we investigated the association between toluene exposure and the CYP2E1 response, as assessed by mRNA content in peripheral lymphocytes or the 6-hydroxychlorzoxazone (6OH-CHZ)/chlorzoxazone (CHZ) quotient (known as CHZ metabolic ratio) in plasma, and the role of genotype (5 -flanking region RsaI/PstI polymorphic sites) in 97 male print workers. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 5 | However, the average CYP2E1 mRNA level in peripheral lymphocytes was 1.07 (0.30-3.08), and CYP2E1 mRNA levels within subjects correlated with the toluene exposure ratio (environmental toluene concentration:urinary hippuric acid concentration) (p = 0.014). | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 6 | However, the average CYP2E1 mRNA level in peripheral lymphocytes was 1.07 (0.30-3.08), and CYP2E1 mRNA levels within subjects correlated with the toluene exposure ratio (environmental toluene concentration:urinary hippuric acid concentration) (p = 0.014). | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 7 | In summary, with further validation, CYP2E1 mRNA content in peripheral lymphocytes could be a sensitive and noninvasive biomarker for the continuous monitoring of toluene effects in exposed persons. | Toluene | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |