Title : Influence of intracerebroventricular administration of cannabinergic drugs on morphine state-dependent memory in the step-down passive avoidance test.

Pub. Date : 2006 May

PMID : 16572001






3 Functional Relationships(s)
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1 The pre-test intracerebroventricular administration of the cannabinoid CB1/CB2 receptor agonist (WIN55,212-2) (0.75 and 1 microg/mouse) not only mimicked the effect of pre-test morphine treatment, but also increased this action of the opioid. Morphine cannabinoid receptor 1 (brain) Mus musculus
2 Furthermore, the pre-test intracerebroventricular administration of CB1 receptor antagonist (AM251) (20 and 100 ng/mouse) prevented the restoration of memory by morphine. Morphine cannabinoid receptor 1 (brain) Mus musculus
3 In conclusion, the improvement of memory retrieval by morphine treatment on the test day seems to be induced, at least in part, by the cannabinoid CB1 receptors. Morphine cannabinoid receptor 1 (brain) Mus musculus