Title : Transcriptional regulation of CD38 expression by tumor necrosis factor-alpha in human airway smooth muscle cells: role of NF-kappaB and sensitivity to glucocorticoids.

Pub. Date : 2006 May

PMID : 16571778






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the present study, we investigated the effects of dexamethasone, a glucocorticoid, on CD38 expression and ADP-ribosyl cyclase activity in HASM cells stimulated with TNF-alpha. Dexamethasone CD38 molecule Homo sapiens
2 In HASM cells, TNF-alpha augmented CD38 expression and ADP-ribosyl cyclase activity, which were attenuated by dexamethasone. Dexamethasone CD38 molecule Homo sapiens
3 The results indicate that TNF-alpha-induced CD38 expression involves NF-kappaB expression and its activation and dexamethasone inhibits CD38 expression through NF-kappaB-dependent and -independent mechanisms. Dexamethasone CD38 molecule Homo sapiens