Pub. Date : 1991 Oct 15
PMID : 1655795
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of GRP78 gene transcription by phorbol ester and cAMP in GH3 pituitary cells. | Cyclic AMP | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 2 | In GH3 cells, optimal induction of GRP78 and translational accommodation depended on cAMP elevation and phorbol ester. | Cyclic AMP | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 3 | GRP78 mRNA was induced 3-6-fold with A23187 alone as compared with 12-20-fold with ionophore plus cAMP-elevating agent and phorbol ester, but was not markedly induced without A23187. | Cyclic AMP | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 4 | GRP78 gene transcription in nuclei isolated from A23187-treated cells was increased 2-4-fold by cAMP and phorbol ester. | Cyclic AMP | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 5 | A nucleotide sequence homologous to the cAMP-responsive element consensus potentially exists in the promoter region of the GRP78 gene. | Cyclic AMP | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 6 | Translational accommodation in ionophore-treated GH3 cells is proposed to involve enhanced transcription of GRP78 mRNA promoted by cAMP/phorbol ester in conjunction with preferential polysomal loading of the message. | Cyclic AMP | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |