Title : An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway.

Pub. Date : 2006 Mar 22

PMID : 16554484






3 Functional Relationships(s)
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1 An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway. Dipeptides glial cell derived neurotrophic factor Homo sapiens
2 We previously showed that leucine-isoleucine (Leu-Ile), an analog of a dipeptide-like structure of FK506 (tacrolimus), induces GDNF expression both in vivo and in vitro. Dipeptides glial cell derived neurotrophic factor Homo sapiens
3 In this investigation, we sought to clarify the cellular mechanisms underlying the GDNF-inducing effect of this dipeptide. Dipeptides glial cell derived neurotrophic factor Homo sapiens