Pub. Date : 1991 Apr 25
PMID : 1652778
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amiloride differentially modulates ANP binding in human thyroid cells and bovine endothelial cells. | Amiloride | natriuretic peptide A | Homo sapiens |
| 2 | The diuretic and sodium channel inhibitor, amiloride, has been shown to increase atrial natriuretic peptide (ANP) binding several fold in certain cell types, but in other tissues it causes only marginal increases in specific ANP binding. | Amiloride | natriuretic peptide A | Homo sapiens |
| 3 | The diuretic and sodium channel inhibitor, amiloride, has been shown to increase atrial natriuretic peptide (ANP) binding several fold in certain cell types, but in other tissues it causes only marginal increases in specific ANP binding. | Amiloride | natriuretic peptide A | Homo sapiens |
| 4 | The diuretic and sodium channel inhibitor, amiloride, has been shown to increase atrial natriuretic peptide (ANP) binding several fold in certain cell types, but in other tissues it causes only marginal increases in specific ANP binding. | Amiloride | natriuretic peptide A | Homo sapiens |
| 5 | We found that amiloride (10(-3) M) increased specific [125I]ANP binding to 750% above control in endothelial cells, but among several thyroid cultures tested the maximal increase in ANP binding with amiloride was only 23% above control. | Amiloride | natriuretic peptide A | Homo sapiens |
| 6 | We found that amiloride (10(-3) M) increased specific [125I]ANP binding to 750% above control in endothelial cells, but among several thyroid cultures tested the maximal increase in ANP binding with amiloride was only 23% above control. | Amiloride | natriuretic peptide A | Homo sapiens |
| 7 | Moreover, most of the thyroid cultures showed decreased ANP binding in the presence of amiloride. | Amiloride | natriuretic peptide A | Homo sapiens |
| 8 | The increased ANP binding in endothelial cells exposed to amiloride is best explained by an increased affinity of the receptor for its ligand since the drug lowered the Kd of ANP binding from 0.73 nM to 0.16 nM without affecting the receptor binding capacity. | Amiloride | natriuretic peptide A | Homo sapiens |
| 9 | The increased ANP binding in endothelial cells exposed to amiloride is best explained by an increased affinity of the receptor for its ligand since the drug lowered the Kd of ANP binding from 0.73 nM to 0.16 nM without affecting the receptor binding capacity. | Amiloride | natriuretic peptide A | Homo sapiens |
| 10 | The degree of amiloride enhancement of ANP binding in endothelial cells is increased with time in culture (200% above control at 5 days, 750% above at 30 days) suggesting the increase of an amiloride-sensitive receptor relative to an amiloride-insensitive receptor. | Amiloride | natriuretic peptide A | Homo sapiens |
| 11 | The fact that the amiloride-induced decrease in ANP binding in thyroid cells was not exacerbated by pre-incubation with amiloride suggested that the observed amiloride effect was not due to increased receptor internalization with the drug. | Amiloride | natriuretic peptide A | Homo sapiens |
| 12 | These results support a hypothesis that ANP receptor subtypes associated with separate signal transduction mechanisms might be modulated in an opposite manner by the binding of amiloride. | Amiloride | natriuretic peptide A | Homo sapiens |