Pub. Date : 1991
PMID : 1651733
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of TPA on connexin 43 expression in IAR 20 were investigated using northern blot analysis, western blot analysis, and an immunofluorescence technique. | Tetradecanoylphorbol Acetate | gap junction protein, alpha 1 | Rattus norvegicus |
| 2 | Gap-junctional intercellular communication (GJIC) in this cell line decreased within 60 min of 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment and recovered after 24 h. The number of immunofluorescence spots of connexin 43 on IAR 20 was closely related to the change in GJIC induced by TPA. | Tetradecanoylphorbol Acetate | gap junction protein, alpha 1 | Rattus norvegicus |
| 3 | Moreover, connexin 43 protein expression analyzed by western blotting suggests that connexin 43 proteins were still present in TPA-treated cells at a similar level. | Tetradecanoylphorbol Acetate | gap junction protein, alpha 1 | Rattus norvegicus |
| 4 | Moreover, connexin 43 protein expression analyzed by western blotting suggests that connexin 43 proteins were still present in TPA-treated cells at a similar level. | Tetradecanoylphorbol Acetate | gap junction protein, alpha 1 | Rattus norvegicus |
| 5 | These results suggest that GJIC of these rat liver epithelial cells was mediated by connexin 43 protein and that TPA inhibited GJIC by inhibiting posttranslational processing of connexin 43 proteins, e.g., localization or assembly. | Tetradecanoylphorbol Acetate | gap junction protein, alpha 1 | Rattus norvegicus |