Title : Inhibition of the insulin receptor tyrosine kinase by sphingosine.

Pub. Date : 1991 Aug 6

PMID : 1651108






1 Functional Relationships(s)
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1 This lysosphingolipid has been shown previously to inhibit the Ca2+/lipid-dependent protein kinase C. Here we show that insulin-dependent autophosphorylation of partially purified insulin receptor is half-maximally inhibited by 145 microM sphingosine (9 mol %) in Triton X-100 micelles. Octoxynol insulin receptor Homo sapiens