Title : Dietary isoflavone supplementation modulates lipid metabolism via PPARalpha-dependent and -independent mechanisms.

Pub. Date : 2006 Jun 16

PMID : 16507786






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1 Dietary isoflavone supplementation modulates lipid metabolism via PPARalpha-dependent and -independent mechanisms. Isoflavones peroxisome proliferator activated receptor alpha Mus musculus
2 The goal of the present study was to investigate the hypothesis that the effect of isoflavones is mediated through the PPARalpha receptor. Isoflavones peroxisome proliferator activated receptor alpha Mus musculus
3 Isoflavone intake resembled action of fenofibrate on PPARalpha-regulated gene expression, although less robustly compared with fenofibrate. Isoflavones peroxisome proliferator activated receptor alpha Mus musculus
4 We suggest that, at the levels consumed in this study, isoflavone intake is altering lipid metabolism in a manner consistent with activation of PPARalpha and also via a PPARalpha-independent mechanism as well. Isoflavones peroxisome proliferator activated receptor alpha Mus musculus
5 We suggest that, at the levels consumed in this study, isoflavone intake is altering lipid metabolism in a manner consistent with activation of PPARalpha and also via a PPARalpha-independent mechanism as well. Isoflavones peroxisome proliferator activated receptor alpha Mus musculus