Title : Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.

Pub. Date : 2006 Jun 15

PMID : 16507771






1 Functional Relationships(s)
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1 However, bortezomib rapidly induced components of the proapoptotic/terminal UPR, including PERK, the ER stress-specific eIF-2alpha kinase; ATF4, an ER stress-induced transcription factor; and its proapoptotic target, CHOP/GADD153. Bortezomib DNA damage inducible transcript 3 Homo sapiens