Title : Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18.

Pub. Date : 2006 Mar

PMID : 16507336






4 Functional Relationships(s)
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1 Accumulating evidence suggests that regulation of the activity of one such aggrecanase, ADAMTS-4 (or Aggrecanase-1), involves post-translational C-terminal processing (truncation) which modulates both glycosaminoglycan (GAG)-binding affinity and enzymatic activity. Glycosaminoglycans ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens
2 Accumulating evidence suggests that regulation of the activity of one such aggrecanase, ADAMTS-4 (or Aggrecanase-1), involves post-translational C-terminal processing (truncation) which modulates both glycosaminoglycan (GAG)-binding affinity and enzymatic activity. Glycosaminoglycans ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens
3 Accumulating evidence suggests that regulation of the activity of one such aggrecanase, ADAMTS-4 (or Aggrecanase-1), involves post-translational C-terminal processing (truncation) which modulates both glycosaminoglycan (GAG)-binding affinity and enzymatic activity. Glycosaminoglycans ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens
4 Accumulating evidence suggests that regulation of the activity of one such aggrecanase, ADAMTS-4 (or Aggrecanase-1), involves post-translational C-terminal processing (truncation) which modulates both glycosaminoglycan (GAG)-binding affinity and enzymatic activity. Glycosaminoglycans ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens