Title : Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats.

Pub. Date : 2006 Jun

PMID : 16484357






4 Functional Relationships(s)
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1 We first corroborated our earlier work by showing that pro- and active forms of MMP-2 were increased in small renal arteries from pregnant compared with virgin rats and Rlx-treated compared with vehicle-treated nonpregnant rats. Relaxin matrix metallopeptidase 2 Rattus norvegicus
2 MMP-2 mRNA as measured by real-time PCR was increased in small renal arteries from pregnant and Rlx-treated nonpregnant rats compared with their respective controls. Relaxin matrix metallopeptidase 2 Rattus norvegicus
3 Thus increases in MMP-2 mRNA and protein expression are major factors contributing to increased MMP-2 activity in small arteries from pregnant and Rlx-treated nonpregnant rats. Relaxin matrix metallopeptidase 2 Rattus norvegicus
4 Thus increases in MMP-2 mRNA and protein expression are major factors contributing to increased MMP-2 activity in small arteries from pregnant and Rlx-treated nonpregnant rats. Relaxin matrix metallopeptidase 2 Rattus norvegicus