Title : Design and synthesis of potent beta-secretase (BACE1) inhibitors with P1' carboxylic acid bioisosteres.

Pub. Date : 2006 May 1

PMID : 16481167






1 Functional Relationships(s)
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1 Herein, we report BACE1 inhibitors with P1" carboxylic acid bioisosteres in order to develop practical anti-Alzheimer"s disease drugs. Carboxylic Acids beta-secretase 1 Homo sapiens