Title : Molecular alterations of cells resistant to platinum drugs: role of PKCalpha.

Pub. Date : 2006 Jan

PMID : 16473140






2 Functional Relationships(s)
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1 Using display PCR, we found that acquisition of resistance to the multinuclear platinum complex BBR3464 was associated with modulation of several transcripts, including up-regulation of the major substrate of protein kinase C (PKC), the myristoylated alanine-rich C kinase substrate (MARCKS). Platinum myristoylated alanine rich protein kinase C substrate Homo sapiens
2 Using display PCR, we found that acquisition of resistance to the multinuclear platinum complex BBR3464 was associated with modulation of several transcripts, including up-regulation of the major substrate of protein kinase C (PKC), the myristoylated alanine-rich C kinase substrate (MARCKS). Platinum myristoylated alanine rich protein kinase C substrate Homo sapiens