Title : Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis.

Pub. Date : 2006 Apr 11

PMID : 16472828






1 Functional Relationships(s)
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1 Our previous study showed that the addition of 8-oxo-dG to culture media caused an accumulation of 8-oxo-Gua in nuclear DNA in several leukemic cells including KG-1, which lack 8-oxoguanine glycosylase 1 (OGG1) activity due to mutational loss. 7,8-dihydro-8-oxoguanine 8-oxoguanine DNA glycosylase Homo sapiens