Pub. Date : 2006 Feb
PMID : 16472102
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin. | Floxacillin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | However, incubation of human LS 180 colorectal adenocarcinoma cells with flucloxacillin led to a dose-dependent induction of MDR1 as well as of CYP3A4 mRNA, which was also confirmed in primary human hepatocytes. | Floxacillin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | At high concentrations, flucloxacillin activated the human Pregnane-X-Receptor, PXR, a ligand-dependent transcription factor that is the target of many drugs that induce CYP3A4, with consequences for the metabolism of other drugs. | Floxacillin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | These findings indicate that flucloxacillin has the potential to induce expression of both CYP3A4 as well as P-glycoprotein, most likely through activation of the nuclear hormone receptor PXR. | Floxacillin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |