Title : Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways.

Pub. Date : 2006 Apr 28

PMID : 16467309






1 Functional Relationships(s)
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1 COX-2 induction was accompanied by sustained production of 6-keto-PGF1alpha, the stable hydrolysis product of prostacyclin, and this was inhibited by indomethacin and the COX-2-selective inhibitor NS398. Indomethacin prostaglandin-endoperoxide synthase 2 Homo sapiens