Pub. Date : 2006 Feb 15
PMID : 16459200
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When zinc release from Schaffer collaterals was examined using ZnAF-2, a membrane-impermeable zinc indicator, ZnAF-2 signal in the stratum radiatum of the CA1 was increased by tetanic stimuli at 100 Hz for 1s, suggesting that zinc is released from Schaffer collaterals in a calcium- and impulse-dependent manner. | Calcium | carbonic anhydrase 1 | Homo sapiens |
| 2 | When tetanic stimuli at 100 Hz for 5s were delivered to the dentate granule cells, the increase in calcium signal in the stratum radiatum of the CA1, as well as in the stratum lucidum of the CA3, was attenuated by addition of 10 microM zinc, while enhanced by addition of 1mM CaEDTA, a membrane-impermeable zinc chelator. | Calcium | carbonic anhydrase 1 | Homo sapiens |
| 3 | The increase in calcium signal in the CA1, in which Schaffer collateral synapses exist, during delivery of tetanic stimuli at 100 Hz for 1s to the Schaffer collateral-commissural pathway was also significantly enhanced by addition of 1mM CaEDTA. | Calcium | carbonic anhydrase 1 | Homo sapiens |
| 4 | These results suggest that zinc released from Schaffer collaterals suppressively modulates presynaptic and postsynaptic calcium signaling in the CA1, followed by the suppression of glutamate release. | Calcium | carbonic anhydrase 1 | Homo sapiens |