Title : Activation function-1 domain of estrogen receptor regulates the agonistic and antagonistic actions of tamoxifen.

Pub. Date : 2006 May

PMID : 16455819






2 Functional Relationships(s)
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1 In this report we now show that overexpression of EGFR or activated AKT-2 in MCF-7 cells leads to phosphorylation of Ser167 in the AF-1 domain of ERalpha, enhanced ER-amplified in breast cancer 1 (ER:AIB1) interaction in the presence of tamoxifen, and resistance to tamoxifen. Tamoxifen epidermal growth factor receptor Homo sapiens
2 In this report we now show that overexpression of EGFR or activated AKT-2 in MCF-7 cells leads to phosphorylation of Ser167 in the AF-1 domain of ERalpha, enhanced ER-amplified in breast cancer 1 (ER:AIB1) interaction in the presence of tamoxifen, and resistance to tamoxifen. Tamoxifen epidermal growth factor receptor Homo sapiens