Title : The effect of methadone and buprenorphine on human placental aromatase.

Pub. Date : 2006 Apr 14

PMID : 16455059






1 Functional Relationships(s)
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1 CYP19/aromatase is the major placental enzyme responsible for the metabolism of methadone to 2-ethylidine-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and BUP to norbuprenorphine (norBUP). 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine cytochrome P450 family 19 subfamily A member 1 Homo sapiens