Title : Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cells.

Pub. Date : 2006 Apr 14

PMID : 16452470






2 Functional Relationships(s)
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1 In contrast, ERK1/2 was only phosphorylated with short term nicotine exposure. Nicotine mitogen activated protein kinase 3 Rattus norvegicus
2 MEK inhibitor U0126 abolished nicotine-induced rise in P-ERK1/2, but not P-CREB, nor did it inhibit nicotine-evoked elevation in TH promoter activity, indicating that ERK1/2 was not needed for induction of TH gene expression by nicotine. Nicotine mitogen activated protein kinase 3 Rattus norvegicus