Title : Fibrin clots obtained from plasma containing heparin show a higher sensitivity to t-PA-induced lysis.

Pub. Date : 1992 Jun

PMID : 1643205






4 Functional Relationships(s)
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1 Fibrin clots obtained from plasma containing heparin show a higher sensitivity to t-PA-induced lysis. Heparin plasminogen activator, tissue type Homo sapiens
2 We have evaluated the sensitivity to t-PA-induced lysis of clots prepared from plasma preincubated in vitro with therapeutic concentrations of heparin. Heparin plasminogen activator, tissue type Homo sapiens
3 The extent of t-PA-induced lysis was significantly increased by preincubation of plasma with 0.5 and 1.0 U/ml heparin. Heparin plasminogen activator, tissue type Homo sapiens
4 The concentration of t-PA required to give similar lysis rates were reduced by up to five times after adding 1.0 U/ml heparin to plasma prior to clot formation. Heparin plasminogen activator, tissue type Homo sapiens