Protein Name plasminogen activator, tissue type
Organism Homo sapiens
Gene ID 5327
Gene Symbol


UniProt P00750 (TPA_HUMAN), B4DN26 (B4DN26_HUMAN)
Relationships Total Number of functionally related compound(s) : 1084
Total Number of Articles : 1732

plasminogen activator, tissue type

Gene Summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

  • tissue-type plasminogen activator
  • alteplase
  • plasminogen/activator kringle
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