Title : Structure-activity relationship of polyphenols that inhibit fatty acid synthase.

Pub. Date : 2005 Dec

PMID : 16428296






5 Functional Relationships(s)
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1 Structure-activity relationship of polyphenols that inhibit fatty acid synthase. Polyphenols fatty acid synthase Homo sapiens
2 Here, using nordihydroguaiaretic acid (NDGA), with two phenyl rings connected by a four-carbon chain, as a representative, the structural basis for the inhibition of animal fatty acid synthase (FAS) by polyphenols was investigated. Polyphenols fatty acid synthase Homo sapiens
3 Here, using nordihydroguaiaretic acid (NDGA), with two phenyl rings connected by a four-carbon chain, as a representative, the structural basis for the inhibition of animal fatty acid synthase (FAS) by polyphenols was investigated. Polyphenols fatty acid synthase Homo sapiens
4 A structure-activity relationship study indicated that a biphenyl core exists in all FAS polyphenol inhibitors. Polyphenols fatty acid synthase Homo sapiens
5 Thus, we propose a common model possibly shared by all FAS polyphenol inhibitors. Polyphenols fatty acid synthase Homo sapiens