Pub. Date : 2006 Feb 8
PMID : 16424901
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster. | Iron | aconitase 1 | Mus musculus |
| 2 | The generally accepted role of iron-regulatory protein 1 (IRP1) in orchestrating the fate of iron-regulated mRNAs depends on the interconversion of its cytosolic aconitase and RNA-binding forms through assembly/disassembly of its Fe-S cluster, without altering protein abundance. | Iron | aconitase 1 | Mus musculus |
| 3 | Here, we show that IRP1 protein abundance can be iron-regulated. | Iron | aconitase 1 | Mus musculus |
| 4 | Modulation of IRP1 abundance by iron did not require assembly of the Fe-S cluster, since a mutant with all cluster-ligating cysteines mutated to serine underwent iron-induced protein degradation. | Iron | aconitase 1 | Mus musculus |
| 5 | Modulation of IRP1 abundance by iron did not require assembly of the Fe-S cluster, since a mutant with all cluster-ligating cysteines mutated to serine underwent iron-induced protein degradation. | Iron | aconitase 1 | Mus musculus |
| 6 | Phosphorylation of IRP1 at S138 favored the RNA-binding form and promoted iron-dependent degradation. | Iron | aconitase 1 | Mus musculus |
| 7 | Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly. | Iron | aconitase 1 | Mus musculus |
| 8 | Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly. | Iron | aconitase 1 | Mus musculus |