PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16424901-0	2006	Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.	Iron	0-4	aconitase 1	Mus musculus	31-56	
16424901-1	2006	The generally accepted role of iron-regulatory protein 1 (IRP1) in orchestrating the fate of iron-regulated mRNAs depends on the interconversion of its cytosolic aconitase and RNA-binding forms through assembly/disassembly of its Fe-S cluster, without altering protein abundance.	Iron	31-35	aconitase 1	Mus musculus	58-62	
16424901-2	2006	Here, we show that IRP1 protein abundance can be iron-regulated.	Iron	49-53	aconitase 1	Mus musculus	19-23	
16424901-3	2006	Modulation of IRP1 abundance by iron did not require assembly of the Fe-S cluster, since a mutant with all cluster-ligating cysteines mutated to serine underwent iron-induced protein degradation.	Iron	32-36	aconitase 1	Mus musculus	14-18	
16424901-3	2006	Modulation of IRP1 abundance by iron did not require assembly of the Fe-S cluster, since a mutant with all cluster-ligating cysteines mutated to serine underwent iron-induced protein degradation.	Iron	162-166	aconitase 1	Mus musculus	14-18	
16424901-4	2006	Phosphorylation of IRP1 at S138 favored the RNA-binding form and promoted iron-dependent degradation.	Iron	74-78	aconitase 1	Mus musculus	19-23	
16424901-9	2006	Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly.	Iron	85-89	aconitase 1	Mus musculus	46-50	
16424901-9	2006	Our results reveal a mechanism for regulating IRP1 action relevant to the control of iron homeostasis during cell proliferation, inflammation, and in response to diseases altering cytosolic Fe-S cluster assembly or disassembly.	Iron	190-194	aconitase 1	Mus musculus	46-50