Pub. Date : 2006 Apr
PMID : 16408261
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neonatal quinpirole treatment produced a significant decrease of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the hippocampus that was alleviated by adulthood nicotine treatment. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | Neonatal quinpirole treatment produced a significant decrease of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the hippocampus that was alleviated by adulthood nicotine treatment. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | Interestingly, nicotine treatment to controls produced a significant increase of NGF in the frontal cortex, but a significant decrease of both NGF and BDNF in the hippocampus and BDNF in the frontal cortex. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | Interestingly, nicotine treatment to controls produced a significant increase of NGF in the frontal cortex, but a significant decrease of both NGF and BDNF in the hippocampus and BDNF in the frontal cortex. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | The decreases shown in NGF and BDNF is contrary to past findings that have shown nicotine to produce significant increases of hippocampal NGF and BDNF, but these past studies utilized male rats or mice or were performed in vitro. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | This study shows that nicotine has complex interactions with NGF and BDNF in D2-primed and control animals, and emphasizes the importance of gender differences when analyzing nicotine"s effects on neurotrophins. | Nicotine | brain-derived neurotrophic factor | Rattus norvegicus |