Title : Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment.

Pub. Date : 2006 Jun

PMID : 16387351






3 Functional Relationships(s)
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1 The simultaneous study of activation pattern of key proteins of different signaling pathways revealed that cisplatin induced both activation of ERK and p38 and inhibition of P-FAK in the sensitive cells, whereas it progressively failed to elicit such a response in the resistant variants. Cisplatin protein tyrosine kinase 2 Homo sapiens
2 Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment. Cisplatin protein tyrosine kinase 2 Homo sapiens
3 CONCLUSIONS: Our results suggested that emergence of chemoresistance was accompanied with the progressive loss of ERK and p38 activation and with the maintenance of FAK activation in response to cisplatin, and they demonstrated that these alterations were early events in the course of treatments. Cisplatin protein tyrosine kinase 2 Homo sapiens