Title : Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target.

Pub. Date : 2006 Jan 23

PMID : 16380122






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target. hirsutenone matrix metallopeptidase 9 Homo sapiens
2 The upregulation of MMP-9 by TPA was also significantly reduced by hirsutenone. hirsutenone matrix metallopeptidase 9 Homo sapiens
3 In summary, hirsutenone inhibits the TPA-induced upregulation of COX-2 and MMP-9 in human breast epithelial cells, possibly by targeting NF-kappaB, which may contribute to its chemopreventive effects. hirsutenone matrix metallopeptidase 9 Homo sapiens