Title : The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants.

Pub. Date : 2006 Jan

PMID : 16378139






1 Functional Relationships(s)
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1 Our objective was to examine the role of an exogenous nitric oxide (NO) donor, DETA-NONOate (DETA), on matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor of matrix metalloproteinases (TIMP)-1 expression and activity in interleukin (IL)-1beta-induced rat aortic smooth muscle cells (RA-SMCs) and rat aortic explants (RAEs). 2,2'-(hydroxynitrosohydrazono)bis-ethanamine TIMP metallopeptidase inhibitor 1 Homo sapiens