Title : Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.

Pub. Date : 2006 Apr

PMID : 16377763






1 Functional Relationships(s)
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1 Paradoxically, however, Cyp1a1-/- knockout mice are more sensitive to oral benzo[a]pyrene exposure, compared with wild-type Cyp1a1+/+ mice (Mol Pharmacol 65:1225, 2004). pyrene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus