Title : Streptozotocin inhibits O-GlcNAcase via the production of a transition state analog.

Pub. Date : 2006 Feb 10

PMID : 16376298






1 Functional Relationships(s)
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1 Not coincidentally, STZ has also been shown to directly inhibit the O-GlcNAcase activity of the enzyme NCOAT in vitro, which is the only enzyme that possesses the ability to remove O-GlcNAc modifications on proteins in the nucleus and cytosol. Streptozocin O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens