Title : Effects of vitamin D analogs on the expression of plasminogen activator inhibitor-1 in human vascular cells.

Pub. Date : 2006

PMID : 16371233






3 Functional Relationships(s)
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1 RESULTS: In SMC, both paricalcitol and calcitriol down-regulated the expression of PAI-1 mRNA and protein in a dose-dependent manner. paricalcitol serpin family E member 1 Homo sapiens
2 The EC(50) values of paricalcitol and calcitriol on suppressing PAI-1 mRNA were 3.0 and 2.8 nM, respectively. paricalcitol serpin family E member 1 Homo sapiens
3 The effect of paricalcitol on suppressing PAI-1 in SMC was blocked by cycloheximide, suggesting that protein synthesis was involved. paricalcitol serpin family E member 1 Homo sapiens