Pub. Date : 2006 Jun 15
PMID : 16364386
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p38 Mitogen-activated protein kinase mediates IL-8 induction by the ribotoxin deoxynivalenol in human monocytes. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | DON at 500 ng/ml similarly induced p38-dependent IL-8 protein and mRNA expression in PBMC cultures from healthy volunteers. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | Significantly increased IL-6 and IL-1beta intracellular protein and mRNA expression was also observed in PBMC treated with DON (500 ng/ml) which were also partially p38-dependent. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Flow cytometry of PBMC revealed that DON-induced p38 phosphorylation varied among individuals relative to both threshold toxin concentrations (25-100 ng/ml) and relative increases in percentages of phospho-p38(+) cells. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 5 | Flow cytometry of PBMC revealed that DON-induced p38 phosphorylation varied among individuals relative to both threshold toxin concentrations (25-100 ng/ml) and relative increases in percentages of phospho-p38(+) cells. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 6 | DON-induced p38 activation occurred exclusively in the CD14(+) monocyte population. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 7 | Taken together, these data suggest that (1) p38 activation was required for induction of IL-8 and proinflammatory gene expression in the monocyte and (2) DON induced p38 activation in human monocytes via the ribotoxic stress response. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |
| 8 | Taken together, these data suggest that (1) p38 activation was required for induction of IL-8 and proinflammatory gene expression in the monocyte and (2) DON induced p38 activation in human monocytes via the ribotoxic stress response. | deoxynivalenol | mitogen-activated protein kinase 14 | Homo sapiens |