Title : Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment.

Pub. Date : 2006 Jul

PMID : 16362298






4 Functional Relationships(s)
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1 Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2. Folic Acid ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens
2 Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2. Folic Acid ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens
3 Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2. Folic Acid ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens
4 Thus, folate supplementation may have differential effects on chemotherapy: (1) reduction of toxicity, (2) increase of antitumor activity, and (3) induction of MRP1 and BCRP associated cellular drug resistance. Folic Acid ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens